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      斑馬魚(yú)心電測試系統
      作者:admin   時(shí)間:2018-01-17

      CARDIOFISH系統是一款最新開(kāi)發(fā)的檢測成年斑馬魚(yú)心臟功能的產(chǎn)品,該系統可以有效地用于測試藥理學(xué)、安全藥理學(xué)(safety pharmacology)和毒理學(xué) (toxicology)等藥物分子的效果和副作用, 它也是很適合心律失常(arrhythmias )和regener-ation心臟肌肉能力的基礎研究。

       

            

       

      CardioFish系統主要用于斑馬魚(yú)心率監測,系統包括三個(gè)單元:
      1. 機械裝置
      2. 低噪音寬頻模擬放大器
      3. 數據可視化 (visualization),存檔(archiving)和-評測(evaluation)硬件/軟件


      特殊的法拉第籠(The Faraday cage)無(wú)振動(dòng)物體箱固定有系統兩個(gè)主要部件(顯微操作儀和寬頻放大器),它確保完全屏蔽電氣和磁場(chǎng)的干擾,還附帶有一個(gè)小魚(yú)缸和兩個(gè)顯微操作儀,顯微操作儀可以很容易地水平調整和移動(dòng)電極固定器,電極固定器可安裝我們的不銹鋼電極或標準的玻璃電極。


      測量數據(MEASURING DATABASE)

       

       

      采集和分析框架是源自經(jīng)典的并已驗證的記錄和分析系統(Cardiosys),該系統已用于心臟 (cardiac R&D)研發(fā)15年。軟件記錄數據和處理是通過(guò)其中的Cardiofish Z-01軟件來(lái)管理的,它有一個(gè)內置的數據庫架構,所有測量結果自動(dòng)存儲,數據庫可以通過(guò)快捷按鈕打開(kāi)。
       
      斑馬魚(yú)心電記錄(ECG RECORDING)

       

       

      1. 斑馬魚(yú)心電記錄(ECG recordings)可通過(guò)監視畫(huà)面上的快捷按鈕和滾動(dòng)菜單進(jìn)行查看,心電曲線(xiàn)(ECG curve)可應用可視化濾波器或出現的視覺(jué)參數加以改變(如:amplifica-tion、速度), 測量值注釋可以被記錄,各個(gè)數據記錄處理可以單獨的被啟動(dòng)或停止。
      2. 采樣頻率可以在0.5和5 kHz之間調整,同時(shí)提供了一個(gè)合適的低通轉角頻率設置(Nyqvist頻率),可以確??焖俚脑敿毺卣餍盘?QRS)保存。
      3. 斑馬魚(yú)心電(ECG)信號顯示可通過(guò)設置時(shí)間窗口寬度和放大顯示進(jìn)行調整,最優(yōu)化的過(guò)濾效果(50或60Hz陷波濾波器,高通基線(xiàn)過(guò)濾器(刪除breath-related基線(xiàn)振蕩)和低通高頻帶阻濾波器)是由可視化疊加和過(guò)濾信號輔助的,用戶(hù)可以循著(zhù)記錄點(diǎn)進(jìn)行時(shí)間分類(lèi)標注,很容易的截取感興趣的部分進(jìn)行脫機制作分析。
       
      離線(xiàn)分析(OFFLINE ANALYZATIONS )

       

        

          
      記錄的ECG心電圖信號可以在測量后進(jìn)行正確評估或以后任何時(shí)候都可以評估,軟件提供了五種不同的可能性,最典型的(ECG)心電圖參數可以快速計算,以及更復雜的功能,以及更廣泛的選擇:


      1. 單光標分析(One cursor analysis): 一個(gè)應用于收集振幅,在用戶(hù)心電圖(ECG)信號上定義光標位置和HR值被收集到一個(gè)帶統計功能的圖表里。

       

       

       

      2. 經(jīng)典ECG分析(Classical ECG analysis): 評價(jià)心電圖(ECG)的自動(dòng)參數測量,用戶(hù)可從任何一個(gè)可選周期選擇。

       

       

      3. ECG平均分析(ECG averaged analysis): 用戶(hù)定義的持續心電周期( ECG cycles)數可以被同步化和平均化,allow-ing extraction of low amplitude features. 自動(dòng)參數測量可以做到任何用戶(hù)定義平均信號的的時(shí)間范圍。

       

       

      4. 心電圖QT分析(ECG QT analysis): calculating an eligible QT or QTc value, as well as QT
       variability (QTv) as a function of RR or HR, in case of at least 32 chosen cycles.
       Criteria of reliability of the measurements are also evaluated.

       

       

      5. 心臟頻率變化(HRV)分析(Heart frequency variation (HRV) analysis): 心臟頻率的變化是隨時(shí)間和頻率分析而變化的, 也提供有正?;肦R。

       

       
      產(chǎn)品參數:
      1) 程序基于64位操作系統;
      2) 單通道記錄;
      3) 實(shí)時(shí)觀(guān)察和記錄ECG曲線(xiàn);
      4) 屏幕運行時(shí)間:5、10、25或50毫米/秒 ;
      5) 持續的心電(ECG)監護心臟頻率顯示 ;
      6) 網(wǎng)絡(luò )噪音濾波(noise-filtering)算法(50/60Hz陷波濾波器);
      7) 肌肉運動(dòng)(振動(dòng)、顫動(dòng))濾波算法;
      8) 采樣頻率:1000采樣/秒/通道 ;
      9) 放大數: 10000x ;
      10) 輸入阻抗: 10 MΩ symmetric ;
      11) 輸入電阻: 50 Ω;
      12) 總尺寸:400x300x350 mm;
      13) 操縱器 0,05 mm /revolution/25 mm course;
      14) 魚(yú)缸體積:20 ml ;
      15) 魚(yú)缸尺寸大小: 90x40x20 mm ;
      16) 魚(yú)缸材料:陽(yáng)極氧化鋁;
       
      產(chǎn)品相關(guān)文獻:
      STUDYING THE EFFECTS OF FLUORIDE EXPOSURE ON CARDIAC FUNCTION IN ZEBRAFISH (DANIO RERIO) RKov*, GyGazsi, DBencsik, Katalin Bakos, Ferenc Baska, GyGrosz, TamGrosz, BUrbZsolt Csenki Department of Aquaculture, Institute of Environmental and Landscape Management, Faculty of Agricultural and Environmental Sciences, Szent Istv University Pater K. Street 1 H-2100 G (Hungary)


      In the last few decades the effects of fluoride have been well-studied in many organisms. In mammalian models it was found that long-term fluoride exposure changes the ECG profile, prolongation of the P-Q and Q-T intervals were detected. Our aim was to study the effects of chronic fluoride exposure on adult zebrafish and to find out if these effects are similar to those found in mammals.

       

      Fish were treated with 50 ppm, 100 ppm and 200 ppm NaF prior to the ECG measurement. Solutions were changed twice a week during the 3 months study. ECG was measured monthly, for data acquisition and analysis the newly developed zebrafish ECG measurement system (EXPERIMETRIA Ltd.) and the ADVANCE HAEMOSYS haemodynamic software were used. To complete our results, short- term effects of fluoride to heart rate were studied on zebrafish embryos. Embryos were treated with 500 ppm, 400 ppm, 200 ppm, 100 ppm, 50 ppm NaF solutions for 3 days. Embryonic heart rate (HR) was analysed on the basis of 30 second video records.

       

      Results correlated well with the mammalian models. In the third month, significant Q-T prolongation (p<0,05) was found in the 100 ppm (414,83ms) group. The Q-T interval increased in the 3rd month 200 ppm (473,06group too, but it wasnt significant. We also found significant (p<0,05) HR decrease in the 3rd month 200 ppm (101,041/min) group. Embryonic HR increased significantly (p<0,01) on second and third days in the 500 ppm groups.

      This work was supported by GOP-1.1.1.-07/1-2008-0009 and Tprojects.
       
       

       

       

       

       

       

       

       

       

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